Intervening after trauma: Child–Parent Psychotherapy treatment is associated with lower pediatric epigenetic age acceleration
Short summary: This study explored whether a psychosocial treatment to promote safe and responsive parenting in trauma-affected families could reduce epigenetic age acceleration, a health-risk biomarker. Before the treatment, both the intervention and community comparison groups had similar age acceleration levels. After the treatment, the intervention group showed lower age acceleration, suggesting that interventions designed to promote better parent-child relationships may reduce children's biological stress and improve future health.
Scientific abstract: Early-life adversity increases the risk of health problems. Interventions supporting protective and responsive caregiving offer a promising approach to attenuating adversity-induced changes in stress-sensitive biomarkers. This study tested whether participation in an evidence-based dyadic psychosocial intervention, child–parent psychotherapy (CPP), was related to lower epigenetic age acceleration, a trauma-sensitive biomarker of accelerated biological aging that is associated with later health impairment, in a sample of children with trauma histories. Within this quasi-experimental, repeated-measures study, we examined epigenetic age acceleration at baseline and postintervention in a low-income sample of children receiving CPP treatment (n = 45; age range = 2–6 years; 76% Latino) compared with a weighted, propensity-matched community-comparison sample (n = 110; age range = 3–6 years; 40% Latino). Baseline epigenetic age acceleration was equivalent across groups. However, posttreatment, epigenetic age acceleration in the treatment group was lower than in the matched community sample. Findings highlight the potential for a dyadic psychosocial intervention to ameliorate accelerated biological aging in trauma-exposed children.
Authors: Alexandra D. W. Sullivan, Sarah M. Merrill, Chaini Konwar, Michael Coccia, Luisa Rivera, Julia L. MacIsaac, Alicia F. Lieberman, Michael S. Kobor, and Nicole R. Bush